Using a novel regional mapping approach, we found that superagers exhibited a lower burden of frontal WMH, particularly in the juxtacortical and mid-white matter layers, which may contribute to their preserved cognitive performance. This is the first study to apply a detailed topographical analysis of WMH in superagers, reporting that reduced WMH in specific strategic brain areas could serve as a potential neuroimaging marker of the superager-resistant phenotype.
Godoy et al. (Thu,) studied this question.