Clinical Study on Tonifying the Kidney and Activating Blood Circulation Prescription in the Treatment of Osteonecrosis of Femoral Head with Liver-Kidney Deficiency Syndrome

Key Points

• The study aims to evaluate the impact of a kidney-tonifying and blood-activating prescription on osteonecrosis of the femoral head related to liver-kidney deficiency syndrome.
• Included 80 patients with liver-kidney deficiency syndrome and femoral head osteonecrosis.
• Patients were randomly divided into an observation group and a control group, each with 40 participants.
• The observation group received kidney-tonifying and blood-activating treatment, while the control group received a capsule treatment for six months.
• Efficacy and safety were compared between the two groups after treatment.
• Post-treatment, the observation group had a significantly lower traditional Chinese medicine symptom score than the control group (P<0.05).
• Pain visual analog scale scores and biomarker levels for both groups decreased, with the observation group showing greater improvement (P<0.05).
• Bone morphogenetic protein 2 and vascular endothelial growth factor levels improved in the observation group compared to controls (P<0.05).
• No significant differences in ARCO classification stability were noted (P>0.05).
• Both groups showed no significant adverse reactions.