Skull-pting meningeal immunity: Skull bone channels shape neonatal meningeal immune cell trafficking

Key Points

• To investigate how osteoclast-mediated remodeling of skull bone channels affects meningeal immune cell trafficking in neonates.
• Examined the role of osteoclasts in skull bone remodeling.
• Analyzed meningeal immune cell infiltration after challenges.
• Utilized imaging techniques to observe immune cell movement.
• Osteoclast activity significantly remodeled skull bone channels.
• Increased immune infiltration was noted upon challenge in the reconstructed channels.
• Channel changes influenced the variety and quantity of meningeal immune cells present.