Herein, we report an iridium-catalyzed direct asymmetric ring-opening allylation of cyclopropyl alcohols with free allyl alcohols. The catalytic system, consisting of Ir(cod)Cl2, Carreira phosphoramidite ligand, and Fe(ClO4)2·xH2O, enables efficient formation of β-allyl-substituted carbonyl compounds in good yields with excellent enantioselectivities (up to >99% ee). The method exhibits a broad substrate scope, tolerating diverse phenylvinylcarbinol derivatives and both aryl- and alkyl-substituted cyclopropanols.
Jiang et al. (Thu,) studied this question.