Comparison of Transcript and Protein Abundance in Human Donor Retinas Support Extending Postmortem Interval From 12 to 18 Hours to Expand the Donor Pool for Biomedical Research

Key Points

• The study aims to evaluate whether extending the postmortem interval (PMI) from 12 to 18 hours affects the integrity of transcripts and proteins in donor retinas.
• Analyzed transcriptomic integrity in human donor retinas.
• Evaluated proteomic integrity in human donor retinas.
• Compared data between 12 and 18 hours postmortem.
• No significant impact on transcriptomic integrity with extended PMI.
• No significant impact on proteomic integrity with extended PMI.
• PMI extension increases availability of donor eyes for research.