Silent chronic inflammation is the necessary and sufficient condition for the development of cancer. This document unifies Cause 1 (biological pathogens: viruses 85-90%, H. pylori, oncogenic parasites) and Cause 2 (non-organic IARC Group 1 carcinogens 10-15%) under a single etiopathogenetic framework. The final pathway is identical for all agents: penetration → biofilm → silent chronic inflammation → cumulative genomic damage during cell repair → cancer. The organ gradient (permeability + sensitivity) explains why the pancreas has the highest cancer incidence while the heart has zero. The appendix on the naked mole rat (Tian et al., Nature 2013; Zhang et al., Nature 2023) provides direct experimental biological proof: removing the HMM-HA barrier causes cancer to appear even with active oncogenes; maintaining it produces zero cancer. Acute inflammation — which generates immediate alarm signals — never leads to cancer. Silent chronic inflammation — which produces no symptoms for decades — always does. The data belong to peer-reviewed international literature. Someone simply lined them up for the first time.
Luciano Imbimbo (Fri,) studied this question.