Abstract BACKGROUND: Dysregulated oxygen and redox-active metal metabolism create an oxidized tumor microenvironment in non-small cell lung cancer (NSCLC). Tumors accumulate reactive oxygen species (ROS) and labile iron, promoting progression yet creating a vulnerability to iron-catalyzed ROS and lipid peroxidation. This oxidized microenvironment also alters tumor-immune metabolic balance, impeding immune function in the TME. Existing electromagnetic-based therapies such as tumor treating fields and electroporation do not directly target redox-metabolic vulnerabilities and have usability constraints. Building on our recent work published in Cell Metabolism showing that orthogonally applied static electromagnetic fields (EMFs) safely reprogram redox and glucose metabolism to treat diabetes, we sought to determine whether a bioelectromagnetic modality applied during convenient treatment times could be engineered to reprogram tumor-immune metabolism for selective killing of NSCLC. METHODS: We engineered a device to deliver orthogonally oriented static EMFs for ≥6 hours / day. Mice bearing human NSCLC xenografts (H1299 Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 7793.
Huang et al. (Fri,) studied this question.