One vs. 2 vs. ≥3 TET2 mutations in chronic myelomonocytic leukemia: co-mutation patterns and prognostic relevance in the context of contemporary prognostic models including BLAST-mol and CPSS-mol | Synapse
April 7, 2026Open Access
One vs. 2 vs. ≥3 TET2 mutations in chronic myelomonocytic leukemia: co-mutation patterns and prognostic relevance in the context of contemporary prognostic models including BLAST-mol and CPSS-mol
Key Points
The research aims to evaluate the impact of different numbers of TET2 mutations on the prognosis of chronic myelomonocytic leukemia.
Comparison of outcomes across patients with varying numbers of TET2 mutations (one, two, three or more).
Analysis of co-mutation patterns in relation to prognostic models like BLAST-mol and CPSS-mol.
Utilization of contemporary statistical methods to assess overall survival and disease progression.
Patients with ≥3 TET2 mutations showed a poorer prognosis compared to those with fewer mutations.
Co-mutation patterns significantly influenced risk stratification in chronic myelomonocytic leukemia.
Incorporating TET2 mutations into existing prognostic models improved predictive accuracy.