What question did this study set out to answer?

To evaluate the effectiveness of radiation therapy in BRCA1/2 carriers diagnosed with early breast cancer.

April 7, 2026Radiotherapy and Oncology1 citationsOpen Access

Radiation therapy management in BRCA1/2 carriers diagnosed with early breast cancer: An international cohort study

CBCarlotta Becherini EBEva Blondeaux VDVirginia Delucchi

Key Points

To evaluate the effectiveness of radiation therapy in BRCA1/2 carriers diagnosed with early breast cancer.
Analyzed data from the largest international cohort of BRCA1/2 carriers diagnosed with breast cancer at age 40
Compared outcomes of breast-conserving surgery plus radiation therapy versus mastectomy alone
Assessed overall survival and rates of breast events
Overall survival rates were similar for breast-conserving surgery plus radiation therapy and mastectomy alone
Breast-conserving surgery with radiation therapy led to more ipsilateral and contralateral breast events compared to mastectomy
Findings suggest a need for individualized, multidisciplinary treatment approaches for young BRCA carriers

Abstract

Largest international cohort of BRCA1/2 carriers diagnosed with breast cancer at 40 years.OS was similar after BCS plus RT versus MS alone.BCS plus RT was associated with more ipsilateral and contralateral breast events than MS alone.Findings support individualised, multidisciplinary loco-regional decision-making in young BRCA carriers.

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