Dpp6 knockout mice exhibit increased ethanol conditioned place preference and acute ethanol‐induced anxiolytic behavior

Key Points

• The research aims to explore how Dpp6 affects the rewarding and anxiety-reducing properties of ethanol.
• Utilized Dpp6 knockout mice for experimentation
• Conducted conditioned place preference tests for ethanol reward
• Assessed acute ethanol-induced anxiolytic behaviors
• Dpp6 knockout mice showed increased preference for locations associated with ethanol
• Knockout mice exhibited significant anxiolytic behaviors after ethanol administration
• Findings suggest a genetic role for Dpp6 in modulating ethanol effects based on sex