Marine-Derived Quinolinone CHNQD-00603 Triggers Autophagy via Suppressing the AKT/ERK/mTOR Pathway to Reverse Senescence and Restore Osteogenic Potential in Bone Marrow Mesenchymal Stem Cells

Key Points

• The aim is to investigate how CHNQD-00603 affects senescence and osteogenic potential in bone marrow mesenchymal stem cells.
• Examined the impact of CHNQD-00603 on bone marrow mesenchymal stem cells (BMSCs).
• Assessed autophagy activation via the AKT/ERK/mTOR pathway.
• Evaluated changes in senescence and osteogenic capacity.
• CHNQD-00603 significantly reduced BMSC senescence.
• Restoration of osteogenic potential was observed after treatment.
• Regulation of autophagy-related pathways was confirmed.