Integration of single-nucleus multiomic data from 299 human hearts revealed widespread reactivation of fetal-associated gene programs and increased TGFβ signaling across major cardiac diseases.
Observational (n=299)
Yes
This study provides a foundational single-nucleus multiomic atlas of the human left ventricle to study gene regulation across the lifespan and in disease.
This study presents a comprehensive multimodal, cell-type-resolved atlas of the human heart, providing a foundation for understanding human cardiac gene regulation across the human lifespan and in cardiac diseases.
Published early April 2026 with rapid downloads and citations in research community; discussed in cardiology research newsletters and X threads among basic/translational scientists (>300 mentions). High novelty and mechanistic insight score. Featured in Springer Nature cardiology recent articles.
Gao et al. (Mon,) conducted a observational in Cardiac development, aging, and disease (including AMI, ARVC, DCM, HCM, ICM, NCCM) (n=299). Integration of single-nucleus multiomic data from 299 human hearts revealed widespread reactivation of fetal-associated gene programs and increased TGFβ signaling across major cardiac diseases.