Multi-vendor, multi-field strength validation of MRI-Proton density fat fraction for fat quantification: A standardized phantom study

Key Points

• This research aims to validate the accuracy and consistency of MRI-PDFF as a biomarker for liver fat quantification across different MRI vendors and field strengths.
• Conducted a standardized phantom study to assess MRI-PDFF measurement accuracy.
• Evaluated performance across multiple MRI vendors and varying field strengths.
• Analyzed systematic inter-vendor biases and algorithmic differences.
• MRI-PDFF demonstrated accuracy, precision, and consistency for fat quantification.
• Minor systematic biases were found between vendors, attributed to proprietary algorithms.
• Emphasized the need for harmonization in multi-center clinical trials.