A 66-year-old man with a history of prostate adenocarcinoma treated with radiotherapy and endocrine therapy underwent 18F-FDG and 68Ga-PSMA PET/CT. Both scans showed marked radiotracer uptake, raising suspicion for disease recurrence. However, subsequent transurethral resection of the prostate was performed for treatment with concurrent pathologic biopsy, confirmed only chronic inflammation accompanied by focal necrosis and calcification, emphasizing the false-positive risk of these modalities in nonmalignant conditions.
Du et al. (Mon,) studied this question.