Plaque Radiotherapy for Posterior Uveal Melanoma in 4000 Eyes: Analysis of ≥15-Letter Visual Acuity Loss in the Pre-Anti-VEGF Era | Synapse
April 8, 2026
Plaque Radiotherapy for Posterior Uveal Melanoma in 4000 Eyes: Analysis of ≥15-Letter Visual Acuity Loss in the Pre-Anti-VEGF Era
Key Points
The aim is to evaluate the impact of plaque radiotherapy on visual acuity in patients with posterior uveal melanoma before anti-VEGF treatments were available.
Conducted an analysis of 4000 eyes treated with plaque radiotherapy for posterior uveal melanoma.
Measured visual acuity loss classified as ≥15-letter change at a median of 16 months post-treatment.
62% of patients experienced a ≥15-letter loss in visual acuity after treatment.
The findings indicate a substantial proportion of patients lost significant vision following the procedure.
Abstract
In the pre-anti-VEGF days, following treatment of PUM with plaque radiotherapy, visual acuity showed ≥15-letter loss in 62% of patients at median 16 months.