High-frequency endoscopic ultrasound is crucial for the early diagnosis of gastrointestinal tumors. However, achieving high axial resolution, deep tissue signal-to-noise ratio, and real-time data processing simultaneously remains a significant challenge in hardware implementation. This paper proposes a miniaturized real-time high-frequency imaging system based on the Xilinx Artix-7 FPGA. To overcome attenuation limitations of high-frequency signals, we employ a 4-bit Barker code-encoded excitation scheme coupled with a programmable ±100 V high-voltage transmission circuit. This effectively enhances echo energy without exceeding peak voltage safety thresholds. At the receiver end, the system utilizes a multi-channel analog front end integrated with mixed-signal time-gain compensation technology. Furthermore, to address transmission bottlenecks for massive echo data, we designed a Low-Voltage Differential Signaling (LVDS) interface logic based on dynamic phase calibration, ensuring stable, high-speed data transfer to the host computer via USB 3.0. Experimental results with a 20 MHz transducer demonstrate that the system achieves real-time B-mode imaging at 30 frames per second. Phantom testing revealed an axial resolution of 0.13 mm, enabling clear differentiation of 0.1 mm microstructures. Compared to conventional single-pulse excitation, coded excitation technology improved signal-to-noise ratio (SNR) by approximately 4.5 dB at a depth of 40 mm. These results validate the system’s capability for high-precision deep imaging suitable for clinical endoscopy applications, delivered in a compact, low-power form factor.
Gu et al. (Mon,) studied this question.