Acute myocardial infarction impairs coronary vasodilator function globally, affecting both infarcted and remote normal myocardium, which may impact the extent of ischemia and necrosis.
After acute myocardial infarction, there is a severe vasodilator abnormality involving not only resistance vessels in infarcted myocardium, but also those in myocardium perfused by normal coronary vessels. This dysfunction may affect the extent of myocardial ischemia and necrosis after coronary occlusion.
Uren et al. (Thu,) studied this question.