Enhanced biophysical, electrochemical and computational recognition of cancer-relevant G-quadruplex DNA by ferrocenyl curcumin Schiff base motifs

Key Points

• Explore the enhanced recognition of G-quadruplex DNA structures important for gene regulation and cancer.
• Investigated biophysical characteristics of G-quadruplex DNA.
• Utilized electrochemical techniques for detection.
• Applied computational analyses for interaction modeling.
• Improved binding affinity of ferrocenyl curcumin to G-quadruplex DNA.
• Significant electrochemical signal changes observed with target DNA.
• Computational models confirm interaction stability and specificity.

Abstract