What question did this study set out to answer?

This research aims to explore the reliability of elevated thyroglobulin washout in diagnosing thyroid cancer.

April 10, 2026

Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma

Key Points

This research aims to explore the reliability of elevated thyroglobulin washout in diagnosing thyroid cancer.
Presented two case reports of patients with elevated thyroglobulin washout
Documented patient history including iron-handling disorders
Analyzed histopathological findings of cervical lymph nodes
Both cases had benign lymphadenopathy despite high thyroglobulin levels
Iron-handling disorders may complicate the interpretation of thyroglobulin levels
Findings indicate the need for multimodal interpretation in clinical practice

Abstract

Markedly elevated thyroglobulin (Tg) washout is often considered highly suggestive of metastatic differentiated thyroid cancer. We present two cases of false-positive Tg washout in cervical lymph nodes with benign pathology, notably in patients who were carriers of iron-handling disorders. These findings highlight the limitations of Tg washout as a standalone marker and the need for multimodal interpretation.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Shireen S. Gohari

Isaac Wasserman

Justine Philteos

Journals

The Laryngoscope

Actions

Institutions

Harvard University

Massachusetts Eye and Ear Infirmary

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Limitations of Raised Thyroglobulin: Two Cases of Benign Lymphadenopathy Mimicking Thyroid Carcinoma

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider