What question did this study set out to answer?

This study aims to analyze cognitive trajectories in patients following hospitalization for COVID-19 over a 36-month period.

April 10, 2026

Cognitive Trajectories After Hospitalization for COVID-19: A 36-Month Longitudinal Study

Key Points

This study aims to analyze cognitive trajectories in patients following hospitalization for COVID-19 over a 36-month period.
Longitudinal analysis of cognitive function over 36 months post-hospitalization.
Assessment of patients' cognitive performance at multiple time points.
Comparative analysis of cognitive outcomes in different patient subsets.
A fourth subset of patients exhibited a delayed cognitive decline.
Some patients showed stable or improved cognitive function over time.
Chronic cerebral inflammation may contribute to later cognitive impairments.

Abstract

As with many viral encephalitides, some patients showed stable normal or abnormal cognition or improved cognition over time. Surprisingly, however, a fourth subset exhibited delayed cognitive decline. This observation suggests that PASC-associated mechanisms, perhaps including chronic cerebral inflammation, may cause progressive cognitive impairment well after the initial infection clears.

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Authors

Maria Paula Maziero

Eunyoung Lee

Gabriela Delevati Colpo

Journals

Journal of Neuropsychiatry

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Cognitive Trajectories After Hospitalization for COVID-19: A 36-Month Longitudinal Study

Key Points

Abstract

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Discussion

Authors

Journals

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References and Citations

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