What question did this study set out to answer?

To evaluate the efficacy and safety of sildenafil in preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).

April 10, 2026

Sildenafil for bronchopulmonary dysplasia‐associated pulmonary hypertension: A systematic search and narrative synthesis

Key Points

To evaluate the efficacy and safety of sildenafil in preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
Conducted a systematic search for relevant studies
Focused on sildenafil treatment in preterm infants
Narrative synthesis of available evidence
Insufficient evidence supports sildenafil's effect on mortality and morbidity in BPD-PH infants
Calls for more research, especially randomized controlled trials

Abstract

Evidence to support the use of sildenafil treatment for preterm infants with BPD-PH to improve mortality and morbidity is lacking. More research, particularly randomized controlled trials, on the efficacy and safety of sildenafil treatment for preterm BPD-PH infants is needed.

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Discussion

Authors

Yoshinori Katayama

Takatsuki General Hospital

Katsuya Hirata

Osaka Women's and Children's Hospital

Yutaka Nishimura

Hiroshima City Asa Citizens Hospital

Journals

Pediatrics International

Actions

Institutions

Jichi Medical University

Mie University

National Center For Child Health and Development

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Sildenafil for bronchopulmonary dysplasia‐associated pulmonary hypertension: A systematic search and narrative synthesis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study