In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

Key Points

• The central aim is to investigate how maternal hypoxia affects the excitatory neurotransmission in the cingulate cortex, leading to neurodevelopmental disorders.
• Assessed neurodevelopmental disorder-like behaviors in rats exposed to maternal hypoxia.
• Analyzed morphological and functional properties of excitatory pyramidal neurones.
• Examined the balance of excitatory and inhibitory signals in the anterior cingulate cortex.
• Observed deficits in excitatory pyramidal neurones linked to maternal hypoxia exposure.
• Identified a potential excitatory/inhibitory imbalance in the cingulate cortex.
• Proposed enhancing excitatory synaptic response as a therapeutic strategy.

Abstract