Enantioselective Cycloaddition Desymmetrization En Route to Multi-Stereogenic Atropisomers

Key Points

• Investigate a method for the catalytic desymmetrization of prochiral molecules to create chiral architectures.
• Utilized a general organocatalytic approach for asymmetric cycloaddition
• Focused on both biaryl and other prochiral substrates
• Analyzed the enantioselectivity and efficiency of the reactions
• Achieved high enantioselectivity in the synthesized atropisomers
• Demonstrated the versatility of the method with various substrates
• Established a step-economical strategy for constructing complex chiral frameworks

Abstract