Platelet-rich Fibrin as a Biologic Material for Pulp Healing

Abstract Vital pulp therapy is crucial in preserving the function and integrity of dental pulp following exposure due to caries or trauma. Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has emerged as a promising regenerative biomaterial in endodontics. This report presents the management of a grossly carious lower left first permanent molar (tooth 36) in a 9-year-old girl, treated with PRF pulpotomy. The procedure included the removal of infected coronal pulp, application of autologously prepared PRF, followed by a layer of mineral trioxide aggregate and final restoration. Clinical and radiographic evaluations at 1 week, 3 months, and 6 months revealed successful outcomes with no signs of inflammation or periapical pathology. PRF acts as a scaffold, releasing key growth factors such as PDGF and transforming growth factor-β, supporting pulp healing and regeneration. Compared to traditional pulpotomy agents, PRF has shown improved clinical outcomes with fewer side effects. Literature supports its potential in regenerative endodontics with success rates exceeding those of conventional materials. PRF pulpotomy demonstrates favorable clinical and radiographic results in the management of pulpally involved immature permanent teeth. Its biological properties make it a suitable and effective alternative to traditional materials in vital pulp therapy.