Gastric Amyloidosis Presenting as Refractory Dyspepsia: A Diagnostic Challenge

Gastric amyloidosis is a rare condition characterized by localized amyloid deposition in the stomach, often mimicking more common gastrointestinal disorders and presenting diagnostic challenges due to nonspecific symptoms and endoscopic findings. A 62-year-old man with six months of dyspepsia unresponsive to proton pump inhibitors underwent endoscopy, which revealed nodular mucosal changes and erosions in the gastric antrum. Biopsy confirmed amyloid deposits with Congo red staining, and systemic involvement was excluded through comprehensive evaluation. The patient improved with symptomatic management. This case underscores the importance of considering isolated gastric amyloidosis in patients with refractory dyspepsia and atypical gastric lesions, with early biopsy and Congo red staining being essential for accurate diagnosis and appropriate care.