Comparison of HPMCAS Chemical Grades (L, M, and H) for Amorphous Solid Dispersion by Hot-Melt Extrusion. II: Polymer-Drug-Surfactant Miscibility and Drug Release with Itraconazole as a Model Drug

Key Points

• The research aims to evaluate the miscibility of different HPMCAS chemical grades in drug formulations using hot-melt extrusion.
• Comparison of HPMCAS grades (L, M, and H) for creating ASDs.
• Use of itraconazole as a model drug for evaluation.
• Assessment of drug release and surfactant miscibility in various combinations.
• HPMCAS grade significantly affects drug release profiles.
• Hot-melt extrusion proves effective for creating ASDs with improved performance.
• Specific combinations enhance miscibility and release rates compared to spray-drying.