The role of the endoplasmic reticulum-lysosome interaction network in protein homeostasis regulation

Key Points

• The aim is to explore the molecular mechanisms of the endoplasmic reticulum-lysosome interaction network in regulating protein homeostasis.
• Review of existing literature on endoplasmic reticulum and lysosome interactions.
• Discussion of direct and indirect interaction modes within the network.
• Analysis of signaling pathways such as IRE1α, PERK, and ATF6.
• Direct interactions facilitate lipid, ion, and metabolite exchange between the endoplasmic reticulum and lysosome.
• Indirect interactions involve the UPR (unfolded protein response) pathways impacting lysosomal biogenesis and degradation.
• The network coordinates local amino acid supply with global stress signals, influencing protein synthesis and degradation.