Osteosarcoma is the most common poor-prognosis malignant tumor. Bioactive compounds are plant metabolites with diverse pharmacological activities. Although the plant contains medicinal properties like anticancer and antiviral suppressive activities, certain bioactive activities have not been explored yet. The present study aimed to evaluate Vachellia nilotica's bioactive isolated compound for anticancer, antioxidant, cytotoxic, and mineralization in vitro and in silico. Molecular docking demonstrated significant interactions with interleukin 6, SRC protein, Caspase 3, and TP 53 proteins by AutoDock Vina. The present study proved that the isolated compound significantly suppressed MG 63 cell viability in dose- and time-dependent manners. It also exhibited antioxidant activity at low concentrations and low mineralization activity per ALP results. The compound has favorable pharmacokinetic properties and potential for drug development. The present study emphasizes the need for therapy development in osteosarcoma and indicates future research and clinical application directions.
Verma et al. (Thu,) studied this question.