Lifestyle triggers of migraine: Sleep restriction and caffeine lower the threshold for migraine‐like responses in rats in a sex‐specific manner

Key Points

• The study aims to explore how sleep restriction and caffeine affect migraine-like responses in a sex-specific manner in rats.
• Conducted experiments using rats to assess migraine-like responses under different sleep conditions.
• Analyzed the effects of caffeine and sleep restriction on trigeminovascular sensitization.
• Investigated the role of the purinergic system in migraine pathophysiology.
• Sleep restriction was found to enhance migraine-like responses in rats.
• Caffeine was shown to further lower the threshold for these responses.
• The effects observed were different between male and female rats, indicating sex-specific responses.