Causal relationships between somatic movement, brain structures, and mental well-being: A multi-stage Mendelian randomization study

Key Points

• This research aims to investigate the causal links between somatic movement, brain structures, and mental well-being.
• Utilized multi-stage Mendelian randomization to assess causal relationships.
• Examined associations between somatic movement and brain structures.
• Analyzed the impact of sedentary behavior on mental health outcomes.
• Confirmed a causal relationship between somatic movement and mental well-being.
• Identified neural mechanisms linking sedentary behavior to decreased mental well-being.
• Extended previous findings by clarifying the role of brain structures in these relationships.