Chemometric Evaluation of the CUPRAC Assay for Propolis Quality Control: A Decision-Making Framework for Deciphering Antioxidant Paradoxes

Key Points

• The study aims to enhance the understanding of propolis's antioxidant capacity through a chemometric approach.
• Utilized the CUPRAC assay to assess antioxidant levels in propolis samples.
• Analyzed the relationship between total phenolic and flavonoid contents.
• Developed a decision-making framework to evaluate antioxidant paradoxes.
• Revealed that traditional single indicators do not accurately reflect antioxidant capacity.
• Demonstrated complex inter-compound dynamics affecting propolis's antioxidant properties.
• Suggested a more integrated approach for quality control of propolis based on chemometric analysis.