Association of Serum Leptin with Insulin Resistance in Obese and Nonobese Patients with Type 2 Diabetes Mellitus: A Case–control Study from Eastern India | Synapse
April 12, 2026
Association of Serum Leptin with Insulin Resistance in Obese and Nonobese Patients with Type 2 Diabetes Mellitus: A Case–control Study from Eastern India
Key Points
To evaluate the association of serum leptin levels with insulin resistance in obese and nonobese individuals with type 2 diabetes mellitus.
Conducted a case-control study design
Included both obese and nonobese patients with type 2 diabetes
Measured serum leptin levels and assessed insulin resistance
Serum leptin levels showed a significant correlation with insulin resistance in obese patients
No similar association was found in nonobese individuals
Implying leptin could be a useful metabolic risk biomarker for those with obesity and type 2 diabetes
Abstract
The study demonstrated the clinical utility of serum leptin against IR in obese patients with T2DM but not in nonobese individuals, which suggested its potential utility as a metabolic risk biomarker.