Study identifies Aeg-S and Aeg-L as critical inducers of allergic inflammation by Alternaria alternata and reveals their mechanism of immune activation. Their pore-forming activity triggers epithelial breach, IL-33 release, Ca2+ influx, MAPK pathway activation, and cytokine/chemokine expression-events prior to adaptive immune responses against classical allergenic (IgE-reactive) proteins.
Yang et al. (Thu,) studied this question.