Serum N-terminal pro-brain natriuretic peptide levels moderately correlated with regional myocardial strain parameters, including basal anterolateral longitudinal strain, in children with Duchenne muscular dystrophy.
Cross-Sectional (n=38)
No
Does N-terminal pro-brain natriuretic peptide predict cardiac involvement in children with Duchenne muscular dystrophy as detected by advanced echocardiography?
NT-proBNP levels correlate with regional contraction parameters on 3D speckle-tracking echocardiography, suggesting its utility as a biomarker for early cardiac dysfunction in children with Duchenne muscular dystrophy.
Effect estimate: r = 0.407
p-value: p=0.011
This is the first study that includes N-terminal pro-brain natriuretic peptide in conjunction with real-time three-dimensional echocardiography and three-dimensional speckle-tracking echocardiography for assessing cardiac involvement in Duchenne muscular dystrophy patients. The observed correlations between N-terminal pro-brain natriuretic peptide levels and regional contraction parameters hold promise for its relevance as a biomarker for cardiac dysfunction. Prospective studies with a larger population with a broader range of disease severity are necessary in patients with Duchenne muscular dystrophy.
Kaynak et al. (Fri,) conducted a cross-sectional in Duchenne muscular dystrophy (n=38). N-terminal pro-brain natriuretic peptide (NT-proBNP) assessment was evaluated on Correlation between NT-proBNP and basal anterolateral longitudinal strain (r = 0.407, p=0.011). Serum N-terminal pro-brain natriuretic peptide levels moderately correlated with regional myocardial strain parameters, including basal anterolateral longitudinal strain, in children with Duchenne muscular dystrophy.