What question did this study set out to answer?

To evaluate treatment responses and outcomes in patients with traumatic cerebral venous sinus injury (tCVSI) compared to spontaneous cerebral venous sinus thrombosis (CVST).

April 12, 2026

Management and Outcomes of Traumatic Cerebral Venous Sinus Injury Among Patients With Traumatic Brain Injury and Concomitant Intracranial Hemorrhage

Key Points

To evaluate treatment responses and outcomes in patients with traumatic cerebral venous sinus injury (tCVSI) compared to spontaneous cerebral venous sinus thrombosis (CVST).
Multicenter analysis of patients with tCVSI and intracranial hemorrhage.
Comparison of outcomes based on antithrombotic regimens used.
Assessment of recanalization status and its impact on clinical outcomes.
Both antithrombotic regimens showed favorable outcomes post-treatment.
Antithrombotic therapy was linked to reduced mortality in tCVSI patients.
Recanalization status did not correlate with improved clinical outcomes.

Abstract

This multicenter series demonstrates treatment response in patients after tCVSI and describes differences in natural history compared with spontaneous CVST. Both antithrombotic regimens were associated with favorable outcomes, and AP therapy was independently associated with lower mortality, suggesting a potential role in tCVSI management. Recanalization status at follow-up appeared unrelated to clinical outcomes, supporting the need for unique therapeutic approaches for tCVSI compared with spontaneous CVST, particularly in the acute management period.

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Management and Outcomes of Traumatic Cerebral Venous Sinus Injury Among Patients With Traumatic Brain Injury and Concomitant Intracranial Hemorrhage

Key Points

Abstract

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