What question did this study set out to answer?

To evaluate the effectiveness of oxidative stress markers in predicting delayed graft function after kidney transplantation.

April 12, 2026Open Access

Accuracy of oxidative stress markers for predicting delayed graft function lasting longer than a week in deceased-donor kidney transplantation

Key Points

To evaluate the effectiveness of oxidative stress markers in predicting delayed graft function after kidney transplantation.
Evaluated oxidative stress markers in deceased-donor kidney transplant recipients.
Measured donor serum hydrogen peroxide levels.
Analyzed sensitivity and predictive values for delayed graft function.
Hydrogen peroxide level showed 85.7% sensitivity for delayed graft function.
Achieved 91.7% negative predictive value for graft function prediction.
Donor H2O2 ≤14μM effectively classified risk for extended graft function delay.

Abstract

Highlights ■ Oxidative stress markers are associated with the intensity and consequences of ischemia-reperfusion injury during deceased-donor kidney transplantation. ■ The donor’s serum hydrogen peroxide level achieved 85.7% sensitivity and a 91.7% negative predictive value for detecting delayed graft function lasting more than one week. ■ Donor H2O2 ≤14μM is suggested to dichotomize risk for delayed graft function lasting longer than a week. ■ This study provides pivotal information on the use of oxidative stress markers to identify patients at ...

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