This study shows that PVR exhibits a unique metabolic signature distinct from RRD, characterized by the activation of metabolic pathways that support increased energy demand, cellular proliferation, stress responses, and fibrotic remodeling. These findings provide insights into the metabolic mechanisms associated with the progression from RRD to PVR, suggesting potential therapeutic targets to prevent fibrosis and aberrant cell proliferation.
Kawamata et al. (Fri,) studied this question.