What question did this study set out to answer?

This study aims to assess the relationship between serum PAPP-A levels and threatened miscarriage among pregnant women.

April 12, 2026

Comparative Study of Pregnancy-associated Plasma Protein A in Women with Threatened Miscarriage and Normal Pregnant Women at a Tertiary Referral Center

BOBenedetto OsunwusiLagos University Teaching Hospital AOAdeyemi OkunowoUniversity of Lagos GOGbenga Samuel Olorunfemi

Key Points

This study aims to assess the relationship between serum PAPP-A levels and threatened miscarriage among pregnant women.
Comparative analysis of serum PAPP-A levels in women with threatened miscarriage and normal pregnant women.
Measurement of PAPP-A levels and categorization into normal and threatened miscarriage groups.
Assessment of sensitivity and specificity for predicting failed pregnancies based on serum PAPP-A levels.
Serum PAPP-A levels were lower in women with threatened miscarriage compared to normal pregnant women.
A PAPP-A level of <0.63 MoM significantly predicts failed pregnancy with a sensitivity of 77.3% and specificity of 93.4%.
Findings indicate the potential clinical value of PAPP-A in evaluating miscarriage risk.

Abstract

A low maternal serum PAPP-A level was significantly associated with the occurrence of threatened miscarriage and failed pregnancy among pregnant Nigerian women. Serum PAPP-A level of <0.63 MoM significantly predicted the occurrence of failed pregnancy with sensitivity and specificity of 77.3% and 93.4%, respectively. Larger prospective multicenter studies are needed to further investigate the clinical usefulness of maternal serum PAPP-A level in evaluating women with threatened miscarriage in our environment.

AI에게 질문

Bookmark

View Full Paper