Progranulin alleviates cerebral ischemia-reperfusion-induced neuronal ferroptosis via regulating p-STAT3/HSPA5 signaling
Key Points
This research aims to explore how progranulin protects neurons from injury caused by cerebral ischemia-reperfusion.
Examined the effects of progranulin in the context of cerebral ischemia-reperfusion injury.
Analyzed the involvement of p-STAT3 and HSPA5 in signaling pathways.
Conducted experiments to assess neuronal ferroptosis.
Progranulin significantly alleviated ferroptosis in neurons following ischemia-reperfusion injury.
Activation of p-STAT3 and HSPA5 was linked to the protective effects of progranulin.
Abstract
In summary, PGRN protected neurons from the cerebral I/R injury-induced ferroptosis via activating p-STAT3/HSPA5 signaling. Therefore, PGRN may be a therapeutic target for cerebral I/R injury.