Amylase-Responsive Bilayer Film for Sustained Enzyme Delivery and ROS-Scavenging Therapy in Oral Ulcer Treatment

Key Points

• The study aims to improve enzyme delivery and reactive oxygen species (ROS) scavenging in oral ulcer treatment.
• Developed an amylase-responsive bilayer film for sustained enzyme delivery.
• Evaluated the film's retention time and drug bioavailability in vitro.
• Conducted comparative analysis with existing biomaterial-based therapies.
• The bilayer film demonstrated extended retention time in oral environments.
• Significantly enhanced drug bioavailability compared to traditional therapies.
• Effective ROS-scavenging capabilities were confirmed in vitro.