The rapid development of digital technologies is reshaping oral health research and care delivery. However, the translation of these innovations into routine clinical and public health application remains limited. This special communication, jointly developed by the International Association for Dental Research’s Clinical and Translational Science Network and e-Oral Health Network, explores how principles of translational science can be intentionally aligned with e-oral health research to strengthen the impact of digital innovation on oral health outcomes. Drawing on established translational models, this perspective outlines how coordinated bidirectional research approaches can support the progression of digital oral health interventions from early development to sustainable real-world use. Contemporary e-oral health approaches, including virtual care delivery, intelligent decision support systems, mobile and connected technologies, and advanced digital diagnostics, offer new opportunities to enhance disease prevention, clinical decision making, patient engagement, and population-level surveillance. Evidence to date suggests that these approaches can improve diagnostic performance, expand access to care, and support behavior change. Nevertheless, widespread adoption has been hindered by economic, regulatory, ethical, and workforce-related challenges, creating digital inequities. To overcome these barriers, we introduce an integrated translational research framework for e-oral health based on 3 core pillars: 1) technology and capabilities, 2) workforce capacity and training, and 3) real-world patient care, supported by enabling factors including industry and partnerships, policy and governance, and a strong ethics and regulation foundation. By embedding translational research principles into e-oral health development and implementation, this framework seeks to promote methodological rigor, reproducibility, scalability, and equity. Strategic integration of translational science and e-oral health research has the potential to accelerate the uptake of effective digital solutions and contribute to improving oral health outcomes across diverse populations and health systems worldwide. Knowledge Transfer Statement: This special communication, developed by the International Association for Dental Research’s Clinical and Translational Science Network and e-Oral Health Network, explores how translational science frameworks can accelerate integration of digital oral health technologies into practice. Translational science provides structured methods to move innovations from development to implementation, while e-oral health encompasses digital technologies such as teledentistry and artificial intelligence for oral health care delivery. Applying translational principles to e-oral health research can enhance rigor and accelerate evidence-based adoption of digital solutions that improve access and outcomes globally.
Liu et al. (Sat,) studied this question.