Targeting H3K18 Lactylation to Regulate BMP9 Expression and Enhance Osteogenic Differentiation of Periodontal Ligament Stem Cells Under Inflammatory Conditions | Synapse
April 13, 2026
Targeting H3K18 Lactylation to Regulate BMP9 Expression and Enhance Osteogenic Differentiation of Periodontal Ligament Stem Cells Under Inflammatory Conditions
Key Points
This research aims to explore how H3K18 lactylation influences BMP9 expression and osteogenic differentiation in stem cells under inflammation.
Modulation of lactate metabolism
Assessment of H3K18 lactylation levels
Evaluation of BMP9 expression
Analysis of osteogenic differentiation in stem cells under inflammatory conditions
Increased H3K18 lactylation levels were associated with enhanced BMP9 expression.
Osteogenic differentiation of stem cells improved under inflammatory conditions with elevated lactate metabolism.
The findings suggest a potential therapeutic strategy for periodontal tissue regeneration.
Abstract
Modulating lactate metabolism to enhance H3K18la levels and BMP9 expression could be a novel therapeutic strategy for promoting periodontal tissue regeneration in inflammatory conditions.