Association of SCN1A and SCN2A Gene Polymorphisms with Antiseizure Medication Responsiveness: A Case-Control Study from Eastern India

Key Result

SCN1A and SCN2A gene polymorphisms were not significantly associated with antiseizure medication responsiveness in patients from Eastern India.

Key Points

• The aim is to investigate the relationship between SCN1A and SCN2A gene polymorphisms and the effectiveness of antiseizure medications.
• Conducted a case-control study comparing responders and drug-resistant epilepsy individuals.
• Analyzed genotypes of SCN1A and SCN2A gene polymorphisms.
• Assessed the association between specific SNPs and treatment response.
• The AG genotype of SCN2A rs17183814 was found more frequently among responders, but the difference was not statistically significant.
• No significant associations were observed for the SCN1A SNPs with treatment response, aligning with previous findings in Indian populations.