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We describe a germline variant in NUDT15 strongly associated with MP intolerance in childhood ALL, which may have implications for treatment individualization in this disease.
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Jun J. Yang
St. Jude Children's Research Hospital
Wendy Landier
University of Alabama at Birmingham
Wenjian Yang
St. Jude Children's Research Hospital
Journal of Clinical Oncology
Tianjin Chengjian University
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Yang et al. (Tue,) studied this question.
synapsesocial.com/papers/69dcc52e89c4deb67d359ba4 — DOI: https://doi.org/10.1200/jco.2014.59.4671