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April 14, 2026

Relation between sirtuin-1 activity and graft-versus-host disease (GVHD) status post allogeneic haematopoietic stem-cell transplantation (HSCT): Prospective study.

Key Points

To explore the relationship between sirtuin-1 activity and graft-versus-host disease (GVHD) after allogeneic HSCT.
Enrolled thirty patients post-HSCT: 15 with GVHD, 15 without, plus 10 controls.
Measured serum sirtuin-1 levels in patients and controls.
Analyzed ROC curve for GVHD detection sensitivity and specificity.
Serum sirtuin-1 levels significantly higher in GVHD-positive patients (mean 24.6) compared to GVHD-negative (10.8).
ROC analysis showed a cutoff >15.8, with 73.3% sensitivity and 93.3% specificity for GVHD detection.
Positive correlations between sirtuin-1 and ALT; negative correlation with total protein.

Abstract

Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem-cell transplantation (HSCT). This prospective study investigated the role of sirtuin-1 (Sirt-1) activity in GVHD pathogenesis. Thirty patients post-HSCT were enrolled: 15 with GVHD and 15 without, alongside 10 controls. Serum Sirt-1 levels were significantly elevated in GVHD-positive patients (mean 24.6 ± 14.8) compared to GVHD-negative patients (10.8 ± 11.9). ROC curve analysis identified a cutoff >15.8 with 73.3% sensitivity and 93.3% specificity for GVHD detection. Positive correlations were observed between Sirt-1 and ALT, while negative correlations were found with total protein. In conclusion, elevated Sirt-1 levels are associated with GVHD, highlighting its potential as a diagnostic biomarker with high specificity.

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