A photocleavable peptidic Ru(II) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues

Key Points

• The central aim is to improve mass spectrometry imaging for cancer tissues using a new photocleavable mass-tag.
• Developed a photocleavable peptidic Ru(II) mass-tag
• Applied targeted DESI and MALDI mass spectrometry techniques
• Tested in cancer tissue samples
• Improved ionisation efficiency in mass spectrometry
• Enhanced spatial resolution in imaging of cancer tissues
• Demonstrated feasibility for multi-omics analysis in clinical settings