Objective: According to numerous data presented in the scientific sources, the use of minimally manipulated cellular products with their own mesenchymal stem cells (MSCs) improves the results of surgical treatment of bone injuries. However, there is currently no consensus on the preferred use of MSCs from bone marrow or from adipose tissue. This is due to the accumulation of positive experience of their use in the restoration of bone defect. The aim of sudy: Determination of the optimal source of mesenchymal stem cells for surgical reconstruction of a bone defect. The search for publications for the period 2021–2025 was carried out in the databases PubMed, eLIBRARY.RU, Google Scholar and other scientific sources. The selected studies contained data on the use of MSCs from bone marrow and adipose tissue, as well as on the technique of their use. According to the PRISMA criteria, 16 publications were screened, of which 10 did not contain the necessary data on the concentration of cellular components and the technique of their application. Thus, a quantitative analysis of the data from 6 publications was carried out. Results and discussion: Currently, the technique of obtaining and preparing minimally manipulated cellular products with bone marrow MSCs for surgical treatment in traumatology and orthopedics is technically simpler and requires less time than the technique with adipose tissue MSCs. This may be one of the reasons for the prevalence of publications describing the use of bone marrow MSCs in clinical practice. The use of mesenchymal stem cells in the area of surgical reconstruction of a bone defect is necessary, however, there is no consensus on the best source of MSCs. Conclusions: According to the conducted analysis of literary sources, the technique using bone marrow MSCs has an advantage due to the reduction of the operation time, however, the effectiveness of the cellular fraction of the bone marrow aspirate can be significantly reduced by errors in the collection technique and the composition of the aspirate itself. Techniques using adipose tissue MSCs have fewer errors, but a longer intervention time. At the same time, reliably important factors for increasing the effectiveness of bone defects surgical treatment with using minimally manipulated cellular products with MSCs are: heterogeneity and a sufficient amount of cellular fraction (no more than 1 million cells), as well as the presence of a carrier matrix.
Anastasieva et al. (Mon,) studied this question.