ABSTRACT Diabetic foot ulcers are difficult to heal, trapped in a vicious cycle involving excessive high‐glucose exudate, persistent infection, oxidative stress, and impaired cell proliferation. To address these issues, this work presents a multifunctional Janus‐structured fibrous membrane (P/2PHE CaPDA ) capable of regulating the diabetic wound microenvironment. This system integrates anti‐gravity exudate management, photothermal sterilization, Ca 2+ release, and glucose‐responsive drug delivery. The membrane consists of a hydrophobic polylactic acid (PLA) layer and a hydrophilic composite layer (2PHE CaPDA ) containing CaPDA and hyaluronic acid grafted with epigallocatechin gallate (EGCG) via boronate ester bonds. This asymmetric structure, featuring gradient pores and differential wettability, facilitates self‐pumping exudate removal at a rate of 1.96 g·cm − 2 ·h − 1 , driven by the transition of water molecules from van der Waals adsorption to an ordered hydrogen‐bonding network. The CaPDA component provides potent photothermal antibacterial activity (>99% bactericidal efficacy) and releases Ca 2 + to support healing. Meanwhile, the boronate‐linked EGCG enables glucose‐responsive antioxidant release, alleviates oxidative stress, and enhances M2 macrophage polarization by 3.5‐fold relative to baseline. In vivo studies confirmed the material's excellent biocompatibility and its ability to significantly accelerate wound closure. This integrated platform represents a promising strategy for treating infected diabetic wounds.
Wen et al. (Tue,) studied this question.