What question did this study set out to answer?

This research aims to explore the relationship between olfactory decline and tau pathology in Alzheimer's disease.

April 16, 2026Alzheimer s & Dementia0 citationsOpen Access

Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease

KBKamar Bouchouchade Duve Institute LCLisa Collinde Duve Institute CCCéline Coquettede Duve Institute

Key Points

This research aims to explore the relationship between olfactory decline and tau pathology in Alzheimer's disease.
Examined the anatomical-functional link in the olfactory system
Assessed olfactory decline across Alzheimer’s disease stages
Evaluated the potential of smell tests as biomarkers
Establishes a central-to-peripheral spread of tau pathology
Identifies stage-specific olfactory deficits
Suggests targeted smell tests could be early biomarkers for Alzheimer's disease.

Abstract

This anatomical-functional link supports a central-to-peripheral spread of tau pathology in the olfactory system, with stage-specific deficits suggesting targeted smell tests as early AD biomarkers.

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