What question did this study set out to answer?

To investigate the effectiveness of romosozumab and identify predictors of response in women with postmenopausal osteoporosis.

April 16, 2026Osteoporosis International0 citationsOpen Access

Romosozumab super-responders in clinical practice: insights from a large Italian multicenter cohort of women with severe postmenopausal osteoporosis

AGAlberto Ghielmetti GGGiorgia Grassi SCSilvia Carrara

Key Points

To investigate the effectiveness of romosozumab and identify predictors of response in women with postmenopausal osteoporosis.
Analyzed a large Italian multicenter cohort of women with severe postmenopausal osteoporosis.
Assessed bone mineral density (BMD) responses to romosozumab treatment.
Identified predictors associated with BMD improvements.
Substantial proportion of women showed high-magnitude BMD responses.
Bone turnover and age/Z-score for lumbar spine (LS) and prior femoral fracture for femoral neck (FN) were identified as significant predictors.

Abstract

Romosozumab demonstrated high effectiveness in this real-world cohort, with a substantial proportion achieving high-magnitude BMD responses despite extensive prior treatment. Distinct site-specific predictors emerged: bone turnover and age/Z-score for LS, prior femoral fracture for FN.

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